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Index >> Animal Viruses >>Adenoviruses

Adenoviruses

Adenoviruses - A number of different types of adenoviruses have been isolated from a wide variety of species. They generally show the same basic structure. They cause respiratory disease in birds and mammals, and are also implicated in the production of tumours. Adenoviruses are large (80 nm) icosahedral viruses which contain dsDNA. The capsid is composed of 252 roughly spherical morphological subunits arranged on a T=2S lattice.

The morphological units of the, icosahedron faces (hexons, 240) are antigenically distinct from the morphological units at the vertices (pentons, 12). From 12 points of the five-fold, symmetry at the capsid surface extend spike like structures

The three surface antigens are distributed as follows:

(i) The A-antigen (hexon capsomere) forms the faces and edges of the icosahedral capsid.

(ii) The Band C antigens (pentons) form the spike like capsomere, the B-antigen forming the spherical part and the C antigen the spike portion.

The virus particles contain at least 14 protein species. The dsDNA genome constitutes 12-14% by weight of the particle, and is about 35,000 base pairs long. The chromosome has terminally redundant sequences which are identical, but with opposite polarity (invert repeat structures) and are 100- 140 nucleotides long.

Adenovirus DNA is normally linear, but circular structures with and apparently held together by protein are also released from the virion under certain conditions. This DNA is much more infectious. During protein synthesis the precursor mRNA molecules formed have sequences which arc complementary to non contiguous segments on DNA. This indicates that ligation or splicing occurs during mRNA formation, with elimination of intervening precursor segments

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