Orthomyxoviruses -
The
orthomyxoviruses
are
enveloped
viruses
with
helical
nucleocapsids
6-9
nm
in
diameter
and
of
variable
length.
The
particle
is
80-120
nm
in
diameter
and
its
shape
is
pleiomorphic.
The
influenza
virus
is
a
representative
of
orthomyxoviruses.
Three
strains
of
the
influenza
virus,
A,
Band
C
cause
influenza
in
humans.
The
AI
strain
is
the
most
important
because
it
undergoes
constant
antigenic
variation.
The
nucleocapsid
of
orthomyxovirus
is
ribonuclease
sensitive
and
thus
differs
from
the
nucleocapsids
of
other
non
segmented
viruses.
It
shows
a
pseudohelical
morphology.
According
to
one
model
it
consists
of
two
helical
protein
strands
(along
with
RNA).
The
nucleocapsid
is
enclosed
within
an
envelope.
The
internal
ribonucleoprotein
(RNP)
is
normally
not
visible
in
the
intact
virion





