Elongation Process In Translation In Protein Synthesis

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Bacterial Chemotherapy Part 1 Blocking of Antibiotic Transport Inactivation of Antibiotics OR Enzymatic Detoxification Bypass Mechanisms Inhibition of Protein Synthesis Stages of Translation in Protein Synthesis Initiation Process in Translation in Protein Synthesis Elongation Process in Translation in Protein Synthesis Termination Process in Translation in Protein Synthesis

Elongation Process In Translation In Protein Synthesis

Elongation Process In Translation In Protein Synthesis -

(a) Codon recognition. Enzymatic recognition of internal codons in the presence of elongation factors (EF- Tu, EF- Ts), GTP and Mg++ takes place.

(b) Transpeptidation. A peptide bond is formed between initiator fMet-tRNA and the second AA - tRNA by1ransfer of the fMet (peptidyl) group to the second amino acid. MgH and K+ arc required.

(c) Translocation involves:

(i) release of deacylated tRNA fMet,

(ii) one codon movement of mRNA with respect to the ribosome and (iii) movement of peptidyl-tRNA from the A site to the P site.

The internal codon recognition site is now free for the recognition of the next AA-tRNA.

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Bacterial Chemotherapy Part 1 Supernatant Folic Acid Antagonists Aminoalkyl Adenylates Diptheria Toxin 30S/40S Ribosomal Subunits Aminoglycosides Streptomycin Neomycin, Kanamycin and Gentamycin Tetracycines Edeine 50S/60S Ribosomal Subunit Chloramphenicol Macrolides Lincosamides Puromycin Sparsomycin Glutarimides Cycloheximide Ipeal Alkaloids Emetine

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