Index >> Bacterial Cheomotherapy >>Inhibiting DNA Synthesis

Inhibiting DNA Synthesis -Although several compounds inhibit DNA biosynthesis, only a few of them are used clinically as antimicrobial drugs. This is because most inhibitors cannot distinguish between nucleic acid biosynthesis of microorganisms and that their hosts. Inhibitors of nucleic acid­ synthesis fall into two main, groups, (i) those interfering with the synthesis of purine and pyrimidine precursors and (Ii) inhibitors of polymerization.