Inhibition Of Protein Synthesis

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Bacterial Chemotherapy Part 1 Blocking of Antibiotic Transport Inactivation of Antibiotics OR Enzymatic Detoxification Bypass Mechanisms Inhibition of Protein Synthesis Stages of Translation in Protein Synthesis Initiation Process in Translation in Protein Synthesis Elongation Process in Translation in Protein Synthesis Termination Process in Translation in Protein Synthesis

Inhibition Of Protein Synthesis

Inhibition Of Protein Synthesis - Inhibition of protein synthesis is the most frequent mode of antibiotic action. Antibiotics and other inhibitors block protein synthesis in various steps. One way of classifying inhibitors of protein synthesis is based on their site of action: supernatant, the 30S /40S subunit and the 50S /60S subunit. Inhibitors may inhibit protein synthesis in prokaryotes, eukaryotes or both. Prokaryote inhibitors, in general, block protein synthesis in bacteria, mitochondria and chloroplasts.

There are, however exceptions to this generalization. Thus erythromycin, lincomycin and paromomycin inhibit bacterial protein synthesis: but not synthesis in rat liver mitochondria. Inhibitors of, eukaryote protein synthesis generally inhibit protein synthesis in cells having 80S ribosomes.

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Bacterial Chemotherapy Part 1 Supernatant Folic Acid Antagonists Aminoalkyl Adenylates Diptheria Toxin 30S/40S Ribosomal Subunits Aminoglycosides Streptomycin Neomycin, Kanamycin and Gentamycin Tetracycines Edeine 50S/60S Ribosomal Subunit Chloramphenicol Macrolides Lincosamides Puromycin Sparsomycin Glutarimides Cycloheximide Ipeal Alkaloids Emetine

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