Lincosamides

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Bacterial Chemotherapy Part 1 Blocking of Antibiotic Transport Inactivation of Antibiotics OR Enzymatic Detoxification Bypass Mechanisms Inhibition of Protein Synthesis Stages of Translation in Protein Synthesis Initiation Process in Translation in Protein Synthesis Elongation Process in Translation in Protein Synthesis Termination Process in Translation in Protein Synthesis

Lincosamides

Lincosamides - The lincosamides include lincomycin and clindamycin, of which the former has been more extensively studied. Lincomycin is active against many gram positive bacteria, but is inactive against Bram negative species. Its spectrum, therefore, resembles that of penicillin. It does not inhibit protein synthesis in mammalian cells, and shows no activity against 80S ribosomes. It binds exclusively to the 50S subunit of 70S ribosomes and inhibits.

peptide bond synthesis. Lincomycin causes breakdown of poly ribosomes, indicating that lincomycin bound ribosomes cannot remain, attached to mRNA. It inhibits peptide bond synthesis in cell free systems, but probably has no effect on transpeptidation or termination in intact cells.

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Bacterial Chemotherapy Part 1 Supernatant Folic Acid Antagonists Aminoalkyl Adenylates Diptheria Toxin 30S/40S Ribosomal Subunits Aminoglycosides Streptomycin Neomycin, Kanamycin and Gentamycin Tetracycines Edeine 50S/60S Ribosomal Subunit Chloramphenicol Macrolides Lincosamides Puromycin Sparsomycin Glutarimides Cycloheximide Ipeal Alkaloids Emetine

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