Oxamycin -Oxamycin appears to block peptidoglycan biosynthesis immediately beyond the murein precursor formation. This is shown by the fact that when cultures of Staphylococcus aureus are grown in sub inhibiting concentrations of oxamycin, there is accumulation of this compound. Oxamycin inhibits both alanine racemase and D-alanyl-D-alanine syntethase which are required for making the dipeptide for completing the pentapeptide side chain. Oxamycin is structurally related to one possible conformation of D-alanine, and its interfering effect is an example of isosteric interference.
Because of its effect on the central nervous system, oxamycin is used only in TB treatment and that to as a reserve drug when there is resistance to other drugs.
