Streptomycin

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Bacterial Chemotherapy Part 1 Blocking of Antibiotic Transport Inactivation of Antibiotics OR Enzymatic Detoxification Bypass Mechanisms Inhibition of Protein Synthesis Stages of Translation in Protein Synthesis Initiation Process in Translation in Protein Synthesis Elongation Process in Translation in Protein Synthesis Termination Process in Translation in Protein Synthesis

Streptomycin

Streptomycin - Streptomycin was discovered by Waksman in the 1940s. It is active against a wide variety of gram negative and gram positive, bacteria. Its use has become limited because of, two factors: (i) it is not absorbed from the gastro-intestinal tract, and has hence to be injected, and (ii) bacteria readily develop resistance to the drug: streptomycin affects the 70S bacterial ribosomes, but has no effect on 80S eukaryote ribosomes.

The target site appears to be the 30S subunit. The target protein appears to be P10, which is probably an integral part of the acceptor site of the ribosome. It is involved in the binding of aminoacyl t-RNA to the ribosome. Streptomycin acts by inhibiting chain elongation by interfering with AA - tRNA binding to the A-site of the ribosome. Streptomycin also stimulates miscoding at higher concentrations and directly interferes with translocation and peptide bond formation.

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Bacterial Chemotherapy Part 1 Supernatant Folic Acid Antagonists Aminoalkyl Adenylates Diptheria Toxin 30S/40S Ribosomal Subunits Aminoglycosides Streptomycin Neomycin, Kanamycin and Gentamycin Tetracycines Edeine 50S/60S Ribosomal Subunit Chloramphenicol Macrolides Lincosamides Puromycin Sparsomycin Glutarimides Cycloheximide Ipeal Alkaloids Emetine

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