Termination Process In Translation In Protein Synthesis

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Bacterial Chemotherapy Part 1 Blocking of Antibiotic Transport Inactivation of Antibiotics OR Enzymatic Detoxification Bypass Mechanisms Inhibition of Protein Synthesis Stages of Translation in Protein Synthesis Initiation Process in Translation in Protein Synthesis Elongation Process in Translation in Protein Synthesis Termination Process in Translation in Protein Synthesis

Termination Process In Translation In Protein Synthesis

Termination Process In Translation In Protein Synthesis -

(a) Termination codons. Chain elongation continues until a termination codon (UAA, UAG or UGA) is reached and recognized.

(b) Chain release. Release factors cause the release of the protein chain and mRNA. The release factors are RF-1, RF-2 and RF-3 in prokaryotes and RF in eukaryotes. The release factors interact with peptidyl transferase, causing hydrolysis of the bond between tRNA and the polypeptide chain, and thus releasing the chain. The tRNA is also unloaded.

(c) Ribosome dissociation. The 70S ribosome dissociates into its 30S and 50S subunits.

(d) Processing. Formyl methionine or methionine is cleaved after release. In some cases internal cleavage cuts the polypeptide chain into two or more pieces.

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Bacterial Chemotherapy Part 1 Supernatant Folic Acid Antagonists Aminoalkyl Adenylates Diptheria Toxin 30S/40S Ribosomal Subunits Aminoglycosides Streptomycin Neomycin, Kanamycin and Gentamycin Tetracycines Edeine 50S/60S Ribosomal Subunit Chloramphenicol Macrolides Lincosamides Puromycin Sparsomycin Glutarimides Cycloheximide Ipeal Alkaloids Emetine

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