Index >> Bacterial Structure >> RNA-RNA Interactions

RNA-RNA Interactions - There is interaction between the different types of ribosomal RNA, and between ribosomal RNA and other types of cellular RNA(messen­ger RNA and transfer RNA).

5s rRNA-tRNA interaction. As mentioned previously, 58 rRNA forms a specific complex with proteins L5, Lt8 and L25 of the 50S ribosomal subunit.

This 58 rRNA-protein complex binds to the G- T, ψ-C sequence present in loop IV of tRNA.

It has been Suggested that this binding takes place through a complementary C-A-A-G sequence on 58 rRNA.

This polypurine sequence preceds the initiation. codon AUG.

Ribosomal binding sites for all known mRNA molecules contain a sequence of 3-7 polypurine nucleotides preceding the initiation codon.

This sequence is complementary with a polypyrimidine stretch in 168 rRNA.

23S rRNA-5S rRNA interaction. Nucleotides 72-83 of 5S rRNA have been found to be complementary to a 12-nucleotidesequ­ence at the 3' proximal part of 238 rRNA (Herr and Noller, 1975).

238 rRNA also shows base complementary between its two ends. A 7-nucleotide segment near the 3' end is complementary to 7 bases at the 5' end.