Circularization
Of
The
Chromosome
in
Lambda
Phage -
The lambda phage injects a linear DNA molecule into the bacterial cell.
The two complementary single stranded ends, of the linear DNA close simultaneously to form a hydrogen bonded cricle, which is then sealed by a DNA ligase.
Most linear DNA molecules are converted into covalently closed circles within five minutes after infection. The covalently closed circles are also known as RFI, supercoils and species.
I). An intermediate in the formation of the closed circle is the nicked circle form (RFII, species)
II). This consists of a circle with one open and one closed strand.
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