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Index >> Bacteriophages - Part Two >> Excision in Mu Phage

Excision in Mu Phage


Excision in Mu Phage
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The prophage can be excised from the bacterial chromosome, but the excision is usually never precise. A part of the host DNA remains attached at either end of the excised phage DNA. Therefore, the functions of the bacterial genes inactivated by excision are not restored.

The process of induction involves local replication of the prophage, and then recombination with an adjacent point on the host chromosome. This process causes a deletion in the bacterial DNA, and generates a phage bacterial hybrid DNA ring. These rings may contain host genes or integrated episomes.

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