Lysogeny in Temperate Phages

Lysogeny in Temperate Phages

Lysogeny in Temperate Phages - The temperate phages show a wide range of modes of lysogeny, with the phage PI at one end and the Mu phage at the other.

I. The phage PI does not at all integrate its DNA into the host chromosome. It lives as plasmid in lysogenic cells.

2. The phages lambda and P-22 have a highly preferred chromosome, site for integration. In the lambda phage, integration proceeds by recombination of the circular integrative precursors into the host DNA.

Recombination takes place at a specific site (att), and is mediated by specific proteins.

3. The phage P2 has a few preferred sites of integration. There are at least 10 distinct sites on the E. coli chromosome where the P2 genome can integrate.

4. In the Mu phage replication preceeds the formation of integrative precursors into the host DNA. The DNA is integrated randomly into the host genome.

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