Protein
Synthesis-
The
process
of
peptide
synthesis
translation
of
m-RNA
into
peptides,
can
be
divided
into
three
stages-initiation,
elongation
and
termination.
Thanks
to
the
development
of
a
variety
of
techniques,
each
one
of
these
stages
can
now
be
studied
as
partial
reactions
of
the
overall
process
of
translation.
The
process
of
initiation
of
polypeptide
synthesis
needs,
in
addition
to
mRNA
and
formylmethionyl
t-RNA,
the
ribosomes,
GTP
and
at
least
three
initiation
factors,
IF1,
IF2,
and
IF3.
IF1
and
IF3
are
involved
in
the
binding
30
S
ribosomal
particle
to
m-RNA.
IF2
is
involved
in
the
recognition
of
correct
codon
of
m-RNA
by
formyl-methionine
t-RNA.
GTP
is
involved
in
the
positioning
of
formyl
methionine
t-RNA
and
is
subsequently
hydrolysed
to
GDP
and
Pi.
Methionine
plays
a
very
important
role
in
peptide
initiation
in
E.
coli.
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