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Index >> Deoxyribose Nucleic Acid - DNA >> Nucleosides and Nucleotides

Nucleosides and Nucleotides

Nucleosides and Nucleotides -A sugar molecule and a nitrogenous base form a nucleoside, and a nucleoside plus a phosphate group form a nucleotide.In other words a nucleoside is a base-sugar combination and a nucleotide is a nucleoside phosphate.

The nucleotides of RNA are called ribonucleotides, and a nucleoside and of DNA dexoyribonucleotides.

Ribonucleotides contain the sugar ribose and deoxyribonuc1eotides the sugar deoxyribose.The ribose in a nucleoside has free hydroxyl groups on carbons 2'. 3' and 5'.

The phosphate can be attached at aw of these positions. Although all the three nucleoside monophosphate have been found, the most commonly occuring ones are 5' -phosphates and 3' -phosphates.Deoxyribose has only two hydroxyl groups (on carbons 3' and 5') and can thus form only two deoxyribonucleotides, the 3' and the 5' phosphate derivatives.

The nucleosides are usually abbreviated as A, T, G or C, with as a prefix for deoxynucleosides (e. g. dG- is the abbreviation for deoxyguanosine) .

The nucleotides involved in metabolic reactions are generally 5' -phosphate esters of nucleosides. When no number appears before the abbreviation the 5' - ester is implied.

Thus- AMP, ADP and ATP are abbreviations for adenosine-5' -monophosphate, adenosine-5' -diphosphate and adenosine-5' -triphosphate, respectively.

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