Inhibition of Enzymes

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Inhibition of Enzymes

	Inhibition of Enzymes - Certain compounds (e.g. drugs, poisons) combine with an enzyme but do not serve as substrates . They thus block catalysis by the enzyme and function as inhibitors. The inhibitors usually closely resemble the substrate in structure. The enzyme and the inhibitor form an enzyme inhibitor complex which is inactive.
Inhibition may be competitive or non-competitive. In competitive inhibition both inhibitor and substrate molecules compete for binding with the enzyme. If the inhibitor is in sufficiently high concentration it displaces the substrate molecules. Competitive inhibition can be reversed by increasing the concentration of the substrate
In non competitive inhibition the inhibitors (poisons) react with the various functional groups of the enzyme. They inhibit the normal reactions catalysed by the enzyme and result in death. Non competitive inhibition cannot be reversed by increasing the concentration of the substrate.

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