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Malaria

Malaria - The disease was described as early as 5th century ,B.C. There are four recognised species of Plasmodium, that are related to malaria: P. vivax ,p.ovale, P. malariae and P. falciparum, all transmitted by female Anopheles mosquito. This insect consumes human blood to acquire a component for the production of her eggs. The parasite has a very complex life cycle. It takes place partly in mosquito and partly in the human blood.

The parasite enters the blood stream in the sporozite form and immediately invades the liver, where it is very difficult to treat. After several hours, many of the merozites emerge and penetrate the red blood cells.  Thousands of RBCs rupture simultaneously and release tens of thousands of new parasites. At this Point, the victim suffers a malaria attack. There is severe cold, temperature rises rapidly to 104°F - 1O6°p and there is severe headache with mild delirium. After next two or three hours, massive perspiration ends the hot stage.

The patient as a sound sleep till next attack. During this period, the parasite enters a new set of RBC, and repeats the transformation cycle. Plasmodium vivax and P. ovale spend about 48 hr in RBCs and there is a 48 hr interval between attacks. This malaria is called tertian malaria(three days). For P. malariae, the cycle is of about 72 hr - therefore, quartan malaria (four days). The cycle of P. falciparum is not defined and attack may occur at irregular intervals. This type of malaria is called estivo autumnal malaria.

Death from malaria may be due to several factors, related to. loss of red blood cells. The anemia is substantial. The RBC fragments accumulate in the small vessels of brain, kidneys, heart muscle, liver and other vital organs, causing their blockage. Heart attacks, cerebral hemorrhages and venal shutdowns are not uncommon. Quinine is used to treat malaria since its discovery in 1640. Synthetic drug chloroquine is also used for the clinical phase of malaria, and primaquine for dormant phase. Recently mefloquine is also used. Most recently Walter Reed Army Institute for Research in Washington, U.S.A. has developed halofantrine, a new anti-malaria drug that is effective to all forms of multidrug-resistant malaria. Halfan, as the compound known, is shown to cure more than 95% for both, P. vivax and P. falciparum.

 

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