Chemical Mutagens

Chemical Mutagens

Chemical Mutagens -

The first chemical mutagen discovered was mustard 'gas'. In the 1950s chemical mutagens with more or less specific action were developed.

Chemical mutagens can be classified according to the way in which they bring about mutations:

(1) Base analogues which are incorporated into DNA instead of normal bases,

(2) Agents modifying purines and pyridines and agents labilizing bases, and

(3) agents producing distortions in DNA.

The agents in categories (1) and (3) require replication for their action, while agents in category (2) can modify even non replicating DNA.

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Suppressor Genes Frameshift Suppressions Molecular Basis of Mutations Spontaneous Mutations Tautomerism Induced Mutations Chemical Mutagens Base Analogues Agents Modifying Purines and Pyrimidines OR Agents Labilize the Bases Agents Producing Distortions in DNA Radiations Types of Mutations

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