Frameshift Suppressions

Frameshift Suppressions

Frameshift Suppressions -

Certain frameshift mutations resulting from the insertion of nucleotides can also be masked by suppressor genes.In Salmonella typhimurium glycine tRNA contains the nucleotide quadruplet CCCC instead of the triplet CCC in the anticodon position.

The extra nucleotide permits the reading of four nucleotides in mRNA at a time, and thus restores the reading frame to the original position.

In another example the anticodon for phenylalanine tRNA reads the quadruplet UUUC instead of the triplet UUU as the codon for phenylalanine.

It should be noted that mere insertions of an amino acid in the termination codon position it not sufficient to bring about suppression. The inserted amino acid must be able to produce a functional protein

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Suppressor Genes Frameshift Suppressions Molecular Basis of Mutations Spontaneous Mutations Tautomerism Induced Mutations Chemical Mutagens Base Analogues Agents Modifying Purines and Pyrimidines OR Agents Labilize the Bases Agents Producing Distortions in DNA Radiations Types of Mutations

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