Genetic Suppression

Genetic Suppression

Genetic Suppression -

The effect of a mutation on the phenotype can be reversed, so that the original wild type phenotype is brought back. This reversal may be due to true reversion or suppression.

In a true reversion there is a reversal of the original genetic change. A C-->A mutation would change the codon GCU (alanine) to GAD (aspartate).

This may result in the enzyme formed becoming inactive. In a true reversion a reverse mutation from A--->C would restore the Condon for alanine (GAU-->GCU). Such a mutation is called a back mutation.

In a suppression a change at a different site brings about phenotypic correction of the mutation. True reversions can be distinguished from suppressions only suppressed mutants yield recombinants in which the mutant phenotype is again produced.

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Suppressor Genes Frameshift Suppressions Molecular Basis of Mutations Spontaneous Mutations Tautomerism Induced Mutations Chemical Mutagens Base Analogues Agents Modifying Purines and Pyrimidines OR Agents Labilize the Bases Agents Producing Distortions in DNA Radiations Types of Mutations

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