Molecular Basis of Mutations

Gene Mutation
Random Mutations Vs Directed Mutations
Rate of Mutations
Effects of Mutations on the Phenotype
How Does a Mutation Act?
Base Pair Substitutions - Transitions, Transversion, Inversion
Framshift Mutations - Deletion, Insertion
Effect of Change of One Amino Acid in Phenotype
Missense Mutations
Codon Changes and Amino Acid Replacments in Haemoglobins
Nonsense Mutations
Mutation in Termination Codons
Silent Codons
Genetic Supression
Intragenic Suppression
Extragenic OR Intergenic Suppression

Molecular Basis of Mutations

Molecular Basis of Mutations -

Gene mutations at the molecular level involve modification of one base by another, or addition or deletion of one or more bases.

Mutations may be spontaneous or induced.

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Suppressor Genes Frameshift Suppressions Molecular Basis of Mutations Spontaneous Mutations Tautomerism Induced Mutations Chemical Mutagens Base Analogues Agents Modifying Purines and Pyrimidines OR Agents Labilize the Bases Agents Producing Distortions in DNA Radiations Types of Mutations

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