Microbiology Procedure

Index >> Genes >> β-Globin Gene

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Genes All Cases of Genes are DNA Genes of Some Virus are RNA Genome and Plasmon Genes as a Unit of Recombination (Recon) Gene as a Unit of Mutation (Muton) Gene as a Unit of Function (Cistron) Numer of Genes Number of Nucleotides in Average Gene Duplication of Gene

β-Globin Gene

	β-Globin Gene Haemoglobin consists of two alpha and, β polypeptide chains. One of the, β chains is made up of 146 amino acid residues. The gene which codes for this polypeptide chain is' called the, β globin gene. The precursor RNA of mouse, β globin gene has two intervening sequences, one 550 nucleotides long and the other 125 nucleotides long, which are excised during processing to form mRNA. Thus about two thirds of the gene is discarded during processing.
The nucleotide sequences of three of the eight yeast tyrosine-tRNA genes have been determined. Each gene has a 14-base (ATTTAYCACTACGA) intervening sequence in the middle. Similarly phe-tRNA genes have intervening sequences of 18-19 base pairs. It is noteworthy that in all the tRNA gene sequences the intervening sequences are adjacent to the anticodon triplet.
The discovery of split genes has disturbed the concept of colinearity of genes, according to which there is an almost exact correspondence between the nucleotide sequence and the amino acid sequence which it specifies The presence of intervening sequences which do not take part in polypeptide chain formation goes against the colinearity concept. There can no longer be exact correspondence between gene codons and amino acids. The discovery of several examples of split genes in eukaryotes indicates that colinearity between genes and their products may be an exception rather than a rule.

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Gene Regulation Loci and Alleles Split Genes Hexon Gene Ovalbumin Gene β-Globin Gene Genes Within Genes (Overlapping Genes)

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