Microbiology Procedure
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Hexon Gene

Hexon Gene
The DNA of adenovirus is double stranded and codes for about 20 proteins. Eight of the genes are called 'late genes' because they transcribe mRNA late in the virus' life.

The eight late genes transcribe a single RNA which is later cut into eight mRNAs. The total length of the eight mRNAs is, however, less than the length of the original transcript. When one (the hexon gene) of the eight genes was paired with its mRNA the DNA formed three loops which represent the unpaired regions

This indicated that the hexon mRNA was transcribed by four different regions (un looped regions), and that the four segments were then joined together. The looping is obviously a device to exclude unwanted DNA which does not transcribe RNA.

 
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