Ovalbumin
Gene
P. Chambon's group (France) and B. W. O'Malley's group (USA) showed that the ovalbumin gene of chickens is not contiguous but is made up of pieces scattered in the chromosome.
Such genes have been called split genes. Within a gene there may be silent regions which are not represented in the polypeptide chain.
The natural ovalbumin gene transcribes precursor RNA which contains intervening sequences not found in mRNA. The precursor RNA loops out these intervening sequences, which are then excised, to form mRNA
