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Multiple Alleles

Multiple Alleles
So far, it has been observed that a given phenotypic trait of an individual depends on a single pair of genes, each of which occupies a specific position called the gene locus, on a homologous chromosome. Moreover, a particular gene has been found to occur in two alternative forms. For example, a gene (L) for length of Drosophila wings may occur in two alternative forms: a gene (L+) for normal development of wings and a gene (Lvg) for vestigial wings. Because, most flies have normally developed wings, so, it can easily De concluded that gene L + is the original form of gene from which the other form of gene (Lvg) might have originated by certain mutational event at sometime in past. The gene L+ for normal development of wings is called the normal or wild type allele of the gene L and usually symbolized as L+, while the mutated gene Lvg for vestigial wings is called Lvg reduced type or mutant allele of gene L.

A fly with normal wings, thus has two wild type alleles (L+L+) and the vestigial wings fly has two mutant alleles (Lvg Lvg). Both of these allelic forms (L + and Lvg) of gene L occur at corresponding positions on genetically identical (homologous) chromosomes of same or different individual.

But, now there are ample evidences that a gene for a particular character, besides occurring in two alternative forms or alleles may occur in several alternative forms or alleles. All the variants or alleles of a given gene are supposed to be originated by mutation of a single wild type gene. Out of several allelic forms of a gene, a given locus may bear anyone allele, so that, a diploid individual possesses any two alleles of the allelic series. When any of the three or more allelic forms of a gene occupy the same locus in a given pair, of homologous chromosomes they are said to constitute a series of multiple alleles. In other words, all the mutant forms of a single wild type gene constitute a series of multiple alleles.

 

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