One Gene One polypeptide Chain Hypothesis
The hypothesis of one gene-one protein one phenotype relationship has not been found correct by later findings of physiological genetics. There are various evidences in man and in other organisms which suggest that the synthesis and structure of a single protein molecule can be controlled by two or more genes. Recent works have confirmed that single gene controls the production of a single polypeptide chain of protein molecules, therefore, the concept of one gene-one enzyme, now is termed as the concept of one-gene one-polypeptide and it is exemplified by following examples:





