Comparison
of
Lived
Vaccines
and
Killed
Vaccines
Formaldehyde
and β-propiolactone
are
usually
used
for
inactivation
of
virus.
These
agents
inactivate
viral
nucleic
acid
function.
Generally,
a
small
fraction
of
the
population
(approx.
1,000,000,000
particles
make
one
dose)
is
inactivated
far
more
slowly
than
the
majority,
so
that
the
whole
virus
population
has
to
be
kept
in
contact
with
the
inactivating
agent
for
much
longer
period.
There
is
a
danger
of
destruction
of
immunogenicity
during
this
period.
Live
vaccines
present
no
such
problems.
Jonas
Salk
faced
this
type
of
problems
when
he
presented
first
polio
virus
vaccine
(killed)
in
1953
to
the
public.
Albert
Sabin
in
1957
could
produce
successful
live
vaccine
for
polio.
Index >>Immunity >> Comparison of Live Vaccines and Killed Vaccines
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