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Coombs Antoglobulin Test

This is a refinement of the simple agglutination test, and is used when anti-red blood cell antibodies -attach to red cells, but do not agglutinate. Agglutination is induced by the use of an antibody (Coombs serum antiimmunoglobulin to human immunoglobulin prepared in goats or rabbits). This antiimmu­noglobulin reacts with the bound antibody and brings about agglutination of the cells. This test is of value in the detection of anti-red blood cell antibodies associated with such syndromes as haemolytic disease of the new born (erythroblastosis fetalis).