Disulphide
Bonds
Immunoglobulin
molecules
contain
interchain
and
intrachain
disulphide
(-S-S-)
bonds.
lnterchain
disulphide
bonds
are
of
two
types,
HH
bonds
connecting
the
two
heavy
chains
and
HL
bonds
connecting
a
heavy
and
a
light
chain.
Interchain
disulphide
bonds
have
a
stabilizing
role,
but
are
not
essential.
Some
IgA
and
IgD
molecules
do
not
have
HL
disulphide
bonds.
Interchain
disulphide bonds
are
essential
for
conferring
the
particular
structure,
immunoglobulin.
Each
variable
region
and
each
of
the
domains
of
the
constant
region
has
one
intrachain
disulphide
bond,
i.e.
each
110
amino
acid
residue
region
contains
one
bond.
The
two
sulphur
atoms
are
separated
by
about
50-60
amino
acid
residues.
