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Index >>Immunity >> Gell and Coombs Chart of Classification of Hypersensitivity

Gell and Coombs Chart of Classification of Hypersensitivity

Gell and Coombs Chart of Classification of Hypersensitivity

In the early 1970s, P.G.H. Gell and R.A. Coombs proposed another method of classification of hypersensitivity. Their classification is as follows:  1. Immediate hypersensitivity.

It includes three types:

(a) Type I (anaphylactic hypersensitivity). It involves IgE, mast cells, basophils and mediators that induce muscle contraction.

(b) Type II (cytotoxic hypersensitivity). It involves IgG, IgM, complement, and the destruction of host cells

(c) Type III (immune complex hypersensitivity). It involves IgG, IgM, complement, and the formation of antigen-antibody aggregates in the tissues.

2. Delayed hypersensitivity. Described as Type IV (d) Type IV (cellular hypersensitivity). It involves lymphokines and T- Iymphocytes.

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