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Major Histocompatibility Complex MHC

During the 1 970s, immunologists could know that acceptance or rejection of a graft depends largely on a relatively small number of genes called the major histocompatibility genes. Collectively, the genes are known as the major histocompatibility complex. This complex provides the code for a series of cell surface antigens called the histocom­patibility antigens, also known as human leukocyte antigens (HLA) because they were originally studied in leukocytes.