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Type III Immune Complex Hypersensitivity

This type develops when antibodies combine with antigens and form aggregates that accumulate in blood vessels or on tissue surfaces. As complement is activated, the C3a and C5a components increase vascular permeability and exert a chemotactic effect on phagocytic neutrophils, drawing them to the target site. Here the neutrophils, release lysosomal enzymes that cause tissue damage. The antibodies are predominantly IgG, with IgM also found in some cases