Type
III
Immune
Complex
Hypersensitivity
This
type
develops
when
antibodies
combine
with
antigens
and
form
aggregates
that
accumulate
in
blood
vessels
or
on
tissue
surfaces.
As
complement
is
activated,
the
C3a
and
C5a
components
increase
vascular
permeability
and
exert
a
chemotactic
effect
on
phagocytic
neutrophils,
drawing
them
to
the
target
site.
Here
the
neutrophils,
release
lysosomal
enzymes
that
cause
tissue
damage.
The
antibodies
are
predominantly
IgG,
with
IgM
also
found
in
some
cases
