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Index >>Immunity >> Understanding of Antigenic Determinants

Understanding of Antigenic Determinants

Understanding of Antigenic Determinants

In killed vaccines (that consist of whole particles) only a selected surface structure of the virus stimulates immunity, the rest is non immunogenic or the immune response is ineffective. Studies have been made to find these selected structures. Why then not to have a vaccine that has only these structures and not the whole particle? In influenza virus, for example, only four regions of the molecule are involved in building of neutralizing antibody. A vaccine should consist solely of oligopeptides in the correct conformation

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