Understanding
of
Antigenic
Determinants
In
killed
vaccines
(that
consist
of
whole
particles)
only
a
selected
surface
structure
of
the
virus
stimulates
immunity,
the
rest
is
non
immunogenic
or
the
immune
response
is
ineffective.
Studies
have
been
made
to
find
these
selected
structures.
Why
then
not
to
have
a
vaccine
that
has
only
these
structures
and
not
the
whole
particle?
In
influenza
virus,
for
example,
only
four
regions
of
the
molecule
are
involved
in
building
of
neutralizing
antibody.
A
vaccine
should
consist
solely
of
oligopeptides
in
the
correct
conformation
