Antibiotic
Manufacturing-
The
manufacturers
of
antibiotics
maintain
pilot
plant
facilities
whose
purpose
is
to
upgrade
yields
and
to
bring
about
improvements
in
processing
procedures.
Studies
are
continually
being
made
on
strain
improvement,
inoculum
conditions,
fermentation
conditions,
and
various
combinations
of
these
factors.
For
example,
improved
mutant
strains
almost
always
require
adjustments
in
fermentation
conditions
in
order
to
achieve
the
high
yields
in
fermenters
that
are
obtainable
in
shaken
flasks.
