Cephalosporins Production

Cephalosporins Production

Cephalosporins Production - Similar semi synthetic approaches can be used for manufacture of other antibiotics. Cephalosporin C is made as the fermentation product of Cephalosporium acremonium. However, this form is not potent for clinical use. Its molecule can be transformed by removal of an aminoadipic acid side chain to form 7-α aminocephalosporanic acid (7-ACA), which can be further modified by adding side chains to form clinically useful broad spectrum antimicrobials

Various side chains can be added to as well as removed from both 6-APA and 7-ACA to produce antibiotics with varying spectra of activities and varying degrees of resistance to inactivation by enzymes produced by pathogenic microbes. Thus we have entered into the so called third generation cephalosporins, such as moxalactam, developed for control of bacteria that produce enzymes capable of degrading penicillins and cephalosporins

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