Immobilization Definition

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Immobilization Definition

	Immobilization Definition -Immobilisation means "imprisonment or confinement of a biocatalyst in a distinct phase to a suitable inert support, where it can act upon its natural substrate repeatedly and continuously, and can be removed conveniently". For a biocatalyst (enzyme/cell) the substrate is disposed in a bulk phase.
The physically entrapped or covalently bonded biocatalyst is chemically bonded to an inert, insoluble matrix (support), which is a high molecular weight polymer, such as glass beads, starch, cellulose, and polyacrylamide. Since1916, when the phenomenon was reported for the first time by J .M. Nelson and E.G. Griffin, this has been largely used in several manufacturing processes.
They had initially reported the immobilisation (adsorption) of an invertase on charcol/alumina without loss of activity. It was during 1950s and 1960s that the technique became very popular