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Neurotoxins

Neurotoxins - . They interfere with the functioning of nervous system, usually by blocking nerve cell transmission. Neurotoxins, even those produced by members of the same genus, differ markedly in their mode of action.

Neurotoxins responsible for botulism, caused by Clostridium botulinum, bind to nerve synapses, blocking the release of acetycholine from nerve cells of the central nervous system and causing the loss of motor function .The inability to transmit impulses through motor neurons can cause respiratory failure, resulting into death.

The neurotoxin tetanospasmin, produced by Clostridium tetani, causing tetanus, interferes with the peripheral nerves of the spinal cords. The toxin inhibits the ability of these nerve cells to transmit signals to the muscle cells properly, causing the spastic paralysis. As done. by neurotoxin of botulism this toxin also paralyses the motor neurons. The neurotoxin of Shigella dysenteriae, (Shiga toxin), interferes with the circulatory vessels supplying blood to central nervous system rather than affecting nerve cells directly

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