Small Conformational Change in Carrier

Small Conformational Change in Carrier

	Small Conformational Change in Carrier The fixed pore mechanism. Large conformational changes like diffusion and rotation are probably not responsible for transport, because hydrolysis of ATP and transport are tightly coupled processes. Transport probably takes places by small conformational changes in the carrier resulting from its phosphorylation and dephosphorylation.
The carrier is believed to be fixed in place within the membrane and to have a channel or pore through its centre (fixed pore). Conformational change in the carrier protein transports hydrophilic molecules across the membrane. Peripheral proteins could also participate in translocating solutes through fixed pores