Other
Mechanisms
in
Enzyme
Activity -
Other
mechanisms
which
also
play
a
role
in
determining
enzyme
activity
are
covalent
modification
of
enzymes
and
irreversible
inactivation
of
enzymes.
For
example,
glutamine
synthetase
of
E.coli
is
subject
10
modification
by
interaction
with
c-AMP.
The
adenylated
form
is
active
and
adenylation
or
deadenylation
occurs
enzymatically.
Regulation
through
covalent
modification
of
enzyme
does
not
contradict
the
generalization
that
regulation
is
mediated
by
allosteric
proteins.
