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Microorganism Controlling by Chemotherapeutic Agents

Microorganism Controlling by Chemotherapeutic Agents-

It could become possible only since 1940's that a successful treatment of fatal disease was achieved.

Early efforts of microbiologists towards control of diseases were mainly centered at enhancing the role of immune system.

Vaccines for rabies, diphtheria and tetanus were developed. Among the pioneers in this field were Emil von Behring, Elic Metchnikoff, and Paul Ehrlich, all Nobel Prize winners in Physiology or medicine.

Ehrlich. is created with the development of the first chemotherapeutic agent, who conceived the antibody molecules as "magic bullets".

In the early 1900's his attention turned to magic bullets of a purely chemical nature, the chemotherapeutic agents.

Ehrlich and his associates had synthesised hundreds of arsenic-phenol derivatives.

These were tested by one of his associates, Sahachiro Hata, against the syphilis organism.

Later however, their attention focused on a single chemical, compound 606.

This chemical, after trials in animals was made available to physicians under the trade name Salvarsan that soon became the first useful chemotherapeutic drug.

The technical or generic name was arsphenamine. Ehrlich's death in 1915 and the emerging World War eroded the enthusiasm for chemotherapy.

Further progress in this area was made only after about 20 years. German chemists developed some industrial dyes, that exhibited antimicrobial qualities also.

A red dye, prontosil was synthesised in 1932, that showed activity against some Gram positive bacteria such as streptococci and staphyococci.

In 1935, a French group headed by Jacques and Thevese Trefouel announced that sulfanilamide was the active, component of prontosil.

Gerhard Domagk was awarded Nobel Prize in 1939 for successful treatment of war related infections with sulfanilamide.

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