Bacitracin
and
polymyxin,
obtained
from
Bacillus
species
are
used
topically.
The
former
is
used
as
ointment
for
staphylococci,
and
latter
for
Gram-negative
bacilli.
Spectinomycin,
a
product
of
Streptomyces
became
popular
in
late
1970s
as
substitute
for
penicillin
in
case
of
gonorrhea
caused
by
PPNG.
It
is
given
intramuscularly.
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