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Index >> Microbial Control >> Microorganism Controlling by Penicillins

Microorganism Controlling by Penicillins

Microorganism Controlling by Penicillins -

A large group of penicillin derivatives are available. Penicillin G, or benzylpenicillin is the most popular of the penicillin’s.

Other types are penicillin F or penicillin V. All have the basic same structure with a beta-lactam nucleus and several attached groups.

Penicillins are active against a variety of Gram positive bacteria, including staphylococci and streptococci. Penicillin functions during the synthesis of bacterial cell wall.

The molecule blocks the cross-linking of hexoses in the peptidogylycan layer during wall formation, causing bursting of cell.

There are, however, two major drawbacks to the use of penicillin. One, the anaphylactic reaction in those who are allergic to penicillin.

It causes swelling about the eyes or wrists, itchy skin etc. Second, the evolution of some penicillin resistant bacteria, that produce an enzyme, penicillinase.

This converts penicillin into harmless penicilloic acid. Modern Penicillins are mostly produced from Penicillium notatum and P. chrysogenum.

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