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Other
Sites
of
Inhibitions -
Sulphonamides,
sulphones
and
para-
aminosalicylic
acid
are
structural
analogues
of
the
vitamin
para
aminobenzoic
acid.
These
analogues
are
effective
competitors
with
the
natural
substrate
for
the
enzymes
involved
in
synthesis
of
folic
acid,
as
such,
and
thus
inhibit
the
formation
of
this
required
coenzyme
(folic
acid)
causing
a
bacteriostatic
effect.
Trimethoprim
is
an
inhibitor
of
dihydropholate
reductase.
Dihydrofolic
acid
is
a
co
enzyme
required
for
carbon
transfers,
as
those
required
in
synthesis
of
thymidine
and
purines.
This
antibiotic
is
broad
spectrum
one
used
to
treat
bacterial
infections
of
urinary
and
intestinal
tracts.
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