Protein Synthesis Inhibitors

Protein Synthesis Inhibitors

Protein Synthesis Inhibitors -

Such antibiotics are streptomycin, gentamicin, neomycin, kanamycin, tobramycin and amikacin.

These are called aminoglycoside antibiotics, and used for Gram-negative bacteria.

They bind to the 30s ribosomal subunit of the 70s prokaryotic ribosome.

In addition to these, a number of other antibiotics inhibit protein synthesis.

These are tetracyclines, chloramphenicol, erythromycin, lincomycin, clindamycin and Spectinomycin.

Chloramphenicol, unlike others acts primarily by binding to the 50s ribosomal subunit, preventing, he binding of tRNA molecules to both the amino acyl and peptidyl binding sites of the ribosome.

Erythromycin also binds to 50s ribosomal subunit.

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