Negative
Control
of
Transcription
The basic action of these regulatory polypeptides is to combine within or close to the promoter at a region known as the operator. Binding of the regulatory protein to the operator prevents the binding of RNA polymerase to the promoter.
Synthesis of RNA is thus inhibited and no synthesis of protein coded for by the operon occurs. In other words, control is essentially by competition between the RNA polymerase and the regulatory protein for the promoter
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