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Specialised Transduction / Restricted Transduction

Specialised Transduction / Restricted Transduction-The bacterium may remain lysogenic for many generations during which time the viral DNA replicates together with the bacterium. However, at some point in the future, the phage stops coding the repressor protein, and the lytic cycle will begin. The viral DNA that was attached to the chromosome will now break free and direct the synthesis of those proteins that will yield new viruses.

In detaching, however, the viral DNA may carry with it a few bacterial genes from the chromosome. The genes are then replicated along with the viral DNA and they become part of the new phage particles. When the latter are released, copies of the genes are carried along. As the cycle repeats during the next infection, phage DNA enters the new bacterial cells and inserts onto a new chromosome. However, copies of the original, bacterial genes are included, and the bacterium becomes transduced.

The bacterial cell now contains its own genes plus several from the original cell. This type of transduction is called specialised transduction, because specific genes are removed from the bacterial chromosome, depending upon where the viral DNA was attached. This occurs in lambda phage. The removal of genes, however, is thought to be an extremely rare event.

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