Index >> Microbial Metabolism >> Entner Doudroff Pathway

Entner Doudroff Pathway - This pathway of glucose metabolism was first discovered by Entner and Doudoroff who found that Pseudomonas saccharophila released 14CO2 from 1-14C labelled glucose and that the pyruvate produced was labelled differently than in the Embden Meyerhof pathway. The isolation of 2-oxo-3-deoxy-6-phosphogluconate as an intermediate and the discovery of two new enzymes namely dehydratase for 6-phosphogluconate and an aldolase specific for 2-keto 3-deoxy 6-phosphogluconate, led them to formulate the metabolic sequence.