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Index >> Microbial Metabolism >> Glycolysis

Glycolysis

Glycolysis - Glucose, a six carbon compound is degraded by most microorganisms through a series of reactions resulting in the formation of smaller carbon compounds (5,4, 3, 2, carbons). These are then reutilized as building materials either directly or after modifications for the synthesis of nucleic acids, proteins, carbohydrates and lipids.

The overall process involves two types of reactions namely catabolic reactions in which glucose is broken down to smaller fragments and anabolic reactions in which the breakdown products are used in biosynthetic reactions. The former type of reactions are exergonic (energy yielding) reactions and yield energy in the form of ATP while the latter reactions involve the expenditure of energy (endergonic). The catabolic reactions therefore provide the precur­sors as well as energy for the subsequent biosynthesis of macro­ mo1ecules

The complete oxidation of glucose to CO2 and water as in aerobic organisms involves a number of reactions which result in the production of ATP. Which glucose may be broken down by bacteria to CO2 and water. The key intermediate in all these pathways, pyruvate is a C3, keto acid that serves as the starting point for the tricarboxylic acid cycle. (TCA cycle, or Kreb's cycle) which is the major mechanism for oxidation and energy release in aerobic organisms. The tricarboxylic acid cycle, in addition to yielding energy also yields C4 and C5 Units for further biosynthesis.

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