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Microbial Metabolism


Microorganisms, in order to grow must be supplied with energy and other materials such as nitrogen, phosphorus etc. Often, a reduced carbon source such as glucose can serve as the energy source to most organisms. Some organisms can also utilize simple inorganic nitrogen compounds. Bacteria such as E. coli which are complex in composition synthesize all components necessary for growth and multiplication even when grown in a medium containing glucose, an inorganic nitrogen source and minerals. The various ways in which microorganisms metabolise glucose and simple carbon compounds and generate energy as well as basic carbon skeletons essential for the synthesis of macromolecules. These reactions are collectively referred to as "intermediary metabolism" and comprise a series of biosynthetic and degradative reactions catalysed by different enzymes. It is not the purpose of this topic however, to provide all details of the mechanisms by which microorganisms generate energy and synthesise macromolecules since these can be seen in any textbook of biochemistry.