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Structure of Rickettsiae

Structure of Rickettsiae - The rickettsiae (sing. rickettsia) measure about 0.3 - 0.5 µm in diameter and 0.3 -0.4 µm in length and usually appear as rods with rounded edges, a form known as the Coccobacillus. They also exist in alternate shapes and hence pleomorphic.They are hardly visible under the light microscope. They have no flagella, pili, Capsules, or spores. The cell wall is chemically similar to that of Gram negative bacteria and the cytoplasm contains both DNA and RNA as well as many of the enzymes. Reproduction is by binary fission. Except for the organism of trench fever, they do not grow on artificial laboratory media. Living tissues as vertebrate cell cultures, fertilised chicken eggs or live animals are used for their growth. They are, therefore, obligate intracellular parasites.

They are closely associated with arthropods, particularly with arachnids (ticks, mites) and insects (lice, fleas). Rickettsiae infect both humans and arthropods, the latter serving as vectors. Arthropod is a primary host and the human, a secondary host (occasionally reverse may occur). Ticks and mites pass the rickettsiae to their young through the eggs in a process called transovarian infection. When the arthropod feeds in the skin 01 an infected person, it takes a blood meal and becomes infected, particularly along its intestinal tract. As the infected cells of the arthropod burst, the organisms fill the intestinal cavity and are deposited during defecation on the skin of the next individual. By scratching the site, the person himself inoculates the rickettsiae into the blood stream, and symptoms of the disease soon appear.

The symptoms are a high fever lasting for several dark red and a skin rash. The rash begins as pink spots called macules. They progress to pink red spots, like pimples called papules. They soon become dark red and then fade without leaving evidence of scarring. This type of rash is a maculopapular rash. Rickettsiae infections usually respond to treatment with tetracyclines or chloramphenicol.

 

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